| abstract |
A compound of formula (I):-n n whereinn R¹ represents a hydrogen or halogen atom, or a cyano group; R² represents an optionally substituted carbocyclic group having 6 to 10 ring atoms and containing at least one aromatic ring; an optionally substituted heterocyclic group having 5 to 10 ring atoms, including 1 to 4 heteroatoms selected from O,N and S, and containing at least one aromatic ring; or an optionally substituted C₃₋₆cycloalkyl, C₃₋₆cycloalkyl- C₁₋₆alkyl, or C₁₋₁₀alkyl group; R³ and R⁴, which may be the same or different, each represent n a hydrogen or halogen atom, or a C₁₋₆alkyl group optionally substituted by 1 to 3 halogen atoms; and R⁵ represents n a hydrogen atom, a hydroxyl group, or a C₁₋₆alkyl group, optionally substituted by hydroxy, carboxy, amino or mono- or di-(C₁₋₄)alkyl amino, n and salts and other physiologically functional derivative thereof. n The compounds are useful in the treatment of parasitic infections eg. malaria, coccidiosis and Pneumocystis carinii pneumonia. |