abstract |
This invention provides phenyl and heterocyclic derivatives of the formulan or a pharmaceutically acceptable salt or solvate thereof where G isn Arisn n each of A 1 , A 2 , and A3 is independently N or CH;n X is -CO-, -CONH-, -NHCO-, -CH 2 CONH-, -O-, -NH-, -CH 2 -each R 1 is independently - (CH 2 ) n R 3 ; R 2 is C 4 -C 7 straight chain alkyl; each R 3 is independently -OH, -COOH, or 5-tetrazolyl; each n is independently 0, 1, 2, 3, or 4; R 4 is H, OH, halo, nitro, methyl, amino, acetamido, or methanesulfonamido; Q is a bond or -O-; and w is H, methyl, ethyl, or hydroxy. n Their pharmaceutical formulations and their use for antagonizing angiotensin II receptors in mammals. |