| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76195fd1cd08192222699d8e7a88c231 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-3211
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-3264 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-572 |
| filingDate |
1990-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77f5c7ce6af0884f17a7222b3ad8a93d |
| publicationDate |
1991-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0437799-A1 |
| titleOfInvention |
The diastereoselective preparation of phosphinate esters |
| abstract |
An increase in the diastereoselectivity resulting from the reaction of a phosphinic acid ester of the formulan with the halo ester of the formulan is achieved by carrying out the reaction in the presence of 4-methylmorpholine, diazabicyclooctane, quinuclidine, 1-methylpyrolidine, or cinchonidine. After removal of the R 3 protecting group and fractional crystallization, the resulting desired diastereomeric pair can be resolved, and the desired isomer can be coupled to 4-substituted L-proline to give compounds possessing angiotensin converting enzyme inhibition activity. In particular, the process is useful in producing the antihypertensive agent fosinopril sodium in increased yields. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02088149-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02088149-A3 |
| priorityDate |
1990-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |