| abstract |
The invention relates to the identification of a part of the envelope protein of HIV referred to as the primary neutralization domain. Polypeptides comprising this domain have the ability to develop and / or bind to neutralizing antibodies. The invention also relates to novel HIV polypeptides useful in the diagnosis, prophylaxis or therapy of AIDS. These polypeptides can be prepared according to known synthetic chemical techniques, or by means of recombinant DNA. These polypeptides belong to the gp 120 subunit, amino acids 298-320, comprising the sequence ...... gly-pro-gly ...... and variants thereof. The invention further relates to multepitope polypeptides comprising analogs of this peptide epitope from different variants of HIV. |