abstract |
Derivatives of 9-fluor-prostaglandin have the formula (I), in which R1 represents the groups (a), (b), COOR4 or CONHR5; R2 and R3 each represents a hydrogen atom or a free or functionally transformed hydroxy group; X is a CH2 group, an O or S atom; W represents hydrogen, -OR6, halogen, -CN-, -NO2, trifluoromethyl or COOR6, and in the case where R4 represents hydrogen, their salts with physiologically tolerable bases. The invention relates to alpha-, beta- or gamma clathrates of cyclodextrin, the compounds having formula (I) encapsulated in liposomes, their production process and their pharmaceutical use. |