http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0434727-A4
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_41f1fe22ec49a9beedcd29523f73175a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6869 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-533 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09B47-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-533 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 1989-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f0f4334a21452540a031cf536179b3f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_887348024b2a5b8d746b912de152725d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3089700a355e27e3acf2f54251ad2a56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14d5f9f2a423862a3614869945aee6bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9facba51e92f84adade0a29b0838d90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5fdd7d5edfc9702320f841ab3d5e76e7 |
| publicationDate | 1994-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0434727-A4 |
| titleOfInvention | Red-shifted phthalocyanine and tetrabenztriazaporphyrin reagents |
| abstract | Red-shifted, water-soluble, fluorescent, monomerically-tetherable derivatives having formula (I), wherein M represents either H2 or is selected from among the following metals: aluminum, silicon, phosphorus, gallium, germanium, cadmium, scandium, magnesium, tin, and zinc. Each R1 is independently selected from -XYW, -YW, and -W. X represents either a carbon, or heteroatom selected from among oxygen, nitrogen, sulfur, phosphorus, silicon, and selenium; Y represents a linking group; and W represents a water solubilizing group. The substituent R2 is selected from among -A, -Y'A, -XA, and -XY'A, where A denotes a biological entity such as an antibody, antibody fragment, nucleotide, nucleic acid probe, antigen, oligonucleotide, deoxynucleotide, dideoxynucleotide, avidin, streptavidin or membrane probe, or R2 is a reactive or activatable group suitable for conjugating to a biological entity. Y' is a linking group that tethers the biological entity to the phthalocyanine or tetrabenztriazaporphyrin macrocycle. Z is either a nitrogen atom or a carbon substituted with hydrogen, alkyl, aryl, or aralkyl groups. Z may also be attached to R2. Also disclosed are derivatives of the compounds of formula (I) in which 1-4 of the benzo ring(s) contain 1 or 2 N atoms. Methods of sequencing DNA and detecting analytes, including cells, using these derivatives are disclosed, as are kits for carrying out assays for the analytes and flow cytometry. Methods of detecting DNA using cationic compounds of formula (I), wherein R2 = R1 and W = -N<+>D1D2D3 are also disclosed. Further, compounds containing Tc, Gd, etc. as the metal in formula (I) may be used for imaging or therapy. |
| priorityDate | 1988-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 399.