abstract |
Hybrid molecule containing a cytokine of the hematopoietin receptor super family (or a fragment or analog thereof capable of binding to the receptor of great affinity for this cytokine) covalently linked, at its amino terminal end, to a chemical entity which causes the hybrid molecule to be processed via a lower affinity receptor for this cytokine to a lesser degree than the degree of cytokine processing by the lower affinity receptor, provided that the chemical entity is not a fragment of the diphtheria toxin which comprises the transposition domain of this toxin. |