http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0433427-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3b9f373878f16dc291ff597162e9b344 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4178 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 |
| filingDate | 1990-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8279ce11c4fb389bdb96a8667d01361d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad238b7a5e674ad7b391708ea67b02ee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6693729e3c46fc22e52c20f06b6bc026 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15b16bf0b25af68e35b4e1a029b4edbf |
| publicationDate | 1991-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0433427-A1 |
| titleOfInvention | Combined use of n-imidazolyl derivatives of bicyclic compounds and cyclosporine in therapy |
| abstract | The invention relates to the use of N-imidazolyl derivatives of bicyclic compounds of the general formula (I), in which (a) the alpha compound represents (II) in which Y completes a single bond or represents oxygen or a group - CH2-, and the symbol --- represents a single or double bond, or (b) the alpha compound represents (III) and the symbol --- represents a double bond; one of the following elements R1, R2, R3 and R4 represents -CH2OH, acyl containing 2 to 4 carbon atoms, (IV), -COOR7, -CH2COOR7, (V), (VI) or (VII) in which R7, R8 and R9 each independently represent hydrogen or alkyl containing 1 to 4 carbon atoms, and the others are independently selected from hydrogen, hydroxy, halogen, alkyl containing 1 to 4 carbon atoms, alkoxy containing 1 to 4 carbon atoms and -COOR7 in which R7 is defined as above; one of the elements R5 and R6 represents hydrogen and the other represents hydrogen, C1-C6 alkyl or phenyl; or a pharmaceutically acceptable salt thereof, in particular in combination with cyclosporin A. The compounds obtained are useful for preventing and / or for treating nephrosis induced by cyclosporin A in mammals. |
| priorityDate | 1989-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 131.