| abstract |
The invention relates to new peptides having hypotensive, natriuretic, diuretic, renovasodilation, reno-protective, smooth fiber relaxing and vasorelaxant activities. The new atrial peptides of the invention have the general formula (I), or a salt, an ester or a pharmaceutically acceptable amide thereof, in which R1 is chosen from hydrogen, AcetylArg, Aha, Arg, Cit, His , Lys, Orn and Ser-Ser; R2 represents a group containing sulfur; R3 represents a hydrophobic amino acid or a dipeptide; R4 represents a dipeptide spacer or a tripeptide of the formula X-Y, wherein X represents a dipeptide spacer and Y represents a basic amino acid; R5 represents a hydrophobic amino acid; R6 represents a peptide having up to three amino acids; R7 is selected from Cha, Phe, Cha-Arg, Phe-Arg, (D) Phe-Arg, Phe- (D) Arg, PhepsiArg, Leu-Arg, Ala-Arg, Arg and Gly-Ala; R8 represents a group containing sulfur. |