| abstract |
The invention relates to novel aminoalkylmaleimides having the general formula (I) in which R1 and R2 are the same or are different and represent a hydrogen or a C1-C4 alkyl group, and A represents an alkylene chain of 2 to 6 atoms of carbon, straight or branched, saturated or unsaturated, optionally interrupted by an oxygen or sulfur atom or a carbonyl group, as well as their corresponding acid addition salts. The invention further relates to amidoalkylmaleimide derivatives formed from compounds of general formula (I) and immunological binding partners. In addition, the invention relates to immunological conjugates obtainable by reacting the amidoalkylmaleimide derivatives with peptides or proteins. The present invention also relates to the corresponding processes for the manufacture of the compounds according to the invention, as well as the application of these conjugates in diagnostic analysis methods, in particular in immunoassays. |