| abstract |
The cloning and characterization of a recently isolated gene referred to as saf (secondary metabolism activating factor) is disclosed. Said gene encodes a novel amino acid polypeptide, referred to as SAF polypeptide and modulating, directly or indirectly, the expression of extracellular enzymes in Streptomyces. Also disclosed are units or fragments of DNA encoding said SAF polypeptide, as well as vectors containing said DNA, host organisms transformed by the introduction of said vectors, and methods for the preparation of extracellular enzymes or polypeptides by the culture of such host organisms. |