http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0429223-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_46ffc67cd29dd51dbd0bc0e335dd3994 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D275-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D275-06 |
| filingDate | 1990-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb3abc515dfde6d69947fd76b73810e8 |
| publicationDate | 1991-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0429223-A1 |
| titleOfInvention | Process for preparing enantiomerically pure alpha-amino acids |
| abstract | A process for enantioselectively alkylating, at the asterisked carbon atom, a single enantiomer of a glycine derivative having the general formula ZCO H(R)NY wherein Z is a moiety derived from a chiral sultam, R is hydrogen or C₁ to C₁₀ alkyl and Y is one or more groups rendering the nitrogen atom unreactive towards alkylating agents comprises:n (i) reacting the glycine derivative with an enolising agent to produce the corresponding enolate of the glycine derivative, and (ii) thereafter reacting the enolate of the glycine derivative with an alkylating agent of formula R¹X to generate a singel enantiomer of a product of formula ZCOC(R)(R¹)NY where R¹ is selected from C₁ to C₁₀ alkyl, C₁ to C₂₀ aralkyl, C₂ to C₁₀ alkenyl or substituted dereivatives thereof and X is Cl, Br or I. The product of the process can be treated with first acid and then base to generate the enantiomerically pure alpha-amino acid of formula HO₂CC(R)(R¹)NH₂ and a single enantiomer of the chiral sultam ZH. Preferred examples of the chiral sultam moiety Z aren where R² and R³ are independently hydrogen or C₁ to C₁₀ alkyl and R⁴ is C₁ to C₂₀ alkyl. |
| priorityDate | 1989-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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