http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0427904-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a62b0bdfdf0f7834ffb8daa92ec0e61a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C211-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-88 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B57-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-88 |
| filingDate | 1989-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14b1e990fe5c06662b9f3191c9dc6aa8 |
| publicationDate | 1991-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0427904-A1 |
| titleOfInvention | A process for preparing R(+)-terodiline and salts thereof |
| abstract | A novel process for preparing the R(+)-enantiomer of terodiline (N-tert.butyl-1-methyl-3,3-diphenylpropylamine) and pharmaceutically acceptable salts thereof by optical resolution of a racemic mixture of terodiline using tartaric acid, comprises the steps ofn a) removing a major part of the S(-)-terodiline enantiomer from the racemic mixture of terodiline by precipitation with L(+)-tartaric acid in an organic solvent, b) recovering from the mother liquid of step a) a terodiline product which is enriched in the (+)-enantiomer, c) forming the hydrochloride of said terodiline product in an aqueous solution so as to precipitate R(+)-terodiline hydrochloride from said aqueous solution. n The R(+)-terodiline hydrochloride obtained in step c) is preferablyn d) subjected to one or more re-crystallizations from water. n The R(+)-terodiline hydrochloride obtained from step c) or d) may, if desired,n e) be converted into the free base or into a different pharmaceutically acceptable salt by means of conventional procedures. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5492933-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9510269-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6229190-B1 |
| priorityDate | 1989-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.