| abstract |
Autoimmune diseases can be treated by administration of T cells specific to a T cell receptor, which is present on activated cells, but is absent on unactivated T cells, said T cells being non-specific for the T cells which is specific to the target protein of the autoimmune disease being treated. Said T cell receptor is called an ergotope, since it is an activation marker. Autoimmune diseases can also be treated by administration of T cells, ergotypic protein fragments, containing an ergotope. Said T cells, fragments and ergotypic proteins are used to develop T cells specific to an ergotope in vivo, and therefore attack the natural ergotopes found on autoimmune T cells. |