| abstract |
Controlled flow rate undersaturated dispensing devices (1) for dispensing an agent (5). The initial balanced concentration of agent in agent reservoir (3) and adhesive (5) is less than saturation. The initial charge of the agent in the reservoir (3) is sufficient to prevent in the reservoir (3) a decrease in the activity of the agent of more than 75%, and preferably 25%, during the predetermined duration of the administration. The thicknesses of the adhesive layers (5), of the flow control membrane (4) and of the reservoir (3) are chosen such that at least 50%, and preferably at least 75%, of the The balanced initial charge of agent is in the reservoir layer (3). Said devices (1) can be used to deliver agents which are liquid at body temperature, for example benzotropine, secoverine, nicotine, arecoline, polyethylene glycol monolaurate, glycerol monolaurate, glycerol monooleate and ethanol. |