| abstract |
Compounds of structure: <CHEM> in which X is keto or H and OH; R<1> is H or C1-8alkyl; R<2> is (1) alpha -H, alpha =OH or alpha -acetoxy and/or beta -WCOR<3> where W is a bond or C1-12alkyl and R<3> is C1-8alkyl, C1-8alkoxy of N(R<4>)2 where R<4> is, inter alia, H or C1-8alkyl; (2) =CHWCOR<3> or =CHWOR<5> where W and R<3> are as above and R<5> is, inter alia, phenylalkylcarbonyl, benzoyl, alkoxycarbonyl, aminocarbonyl, alkyl or alkylcarbonyl; (3) alpha -H and beta -NHCOR<6> where R<6> is alkyl or beta -N(R<4>)2 or (4) keto, processes for their preparation, pharmaceutical compositions containing them and their use in therapy as inhibitors of 5- alpha -reductase. |