| abstract |
A TPA derivative with replacement of amino acids is provided. In a typical embodiment, the derivative has an amino acid sequence with replacement of at least one amino acid selected from the group consisting of asparagine at the 37th position, serine at the 38th position, glycine at the 39th position, arginine at the 40th position, alanine at the 41st position, and gluta- mine at the 42nd position from the N-terminus of the amino acid sequence of natural tissue plasminogen activator. |