| abstract |
Disclosed are DNA sequences encoding deletion, substitution and/or addition analogs of the E. coli enzyme, chorismate mutase/prephenate dehydratase (CMPD). Preferred expression products include [des-Gln³⁰⁷, des-Ala³⁰⁸, des-Gly³⁰⁹, des-Ala³¹⁰]CMPD; [Leu³⁰⁶]CMPD; [des-Thr³⁰⁴, Lys³⁰⁵, des-Gln³⁰⁶]CMPD; and [Cys³⁰⁹]CMPD display enzymatic activity of the wild type enzyme but are more resistant to inhibition in the presence of phenylalanine. |