| abstract |
The invention relates to a method for the preparation of lipid microparticles, microcrystalline in appearance, of a water-insoluble substance exhibiting an affinity for phospholipids and at least one phospholipid, the microparticles being stable in suspension in an aqueous solution, wherein: n n a) the abovementioned substance and the abovementioned phospholipid(s) are dissolved in an organic solvent which is a common solvent for the substance and the phospholipid(s), n b) the solution of the substance and of the phospholipid(s) is mixed with an aqueous solution in a quantity such that an insolubilisation in the form of a precipitate takes place, n c) a separation is carried out so as to recover an aqueous solution containing the microparticles in the form of microsuspensions. |