| abstract |
a) on dissout ladite substance et le ou lesdits phospholipides dans un solvant organique commun de ladite substance et du ou desdits phospholipides, b) on mélange la solution de ladite substance et du ou desdits phospholipides à une solution aqueuse dans une quantité telle qu'une insolubilisation sous forme de précipité se produit, c) on élimine pour récupérer une solution aqueuse contenant les microparticules sous forme de microsuspensions. The subject of the present invention is a process for the preparation of lipid microparticles of microcrystalline appearance of a substance insoluble in water having an affinity for phospholipids, and at least one phospholipid, stable microparticles in suspension in an aqueous solution, characterized in that: a) dissolving said substance and said phospholipid (s) in a common organic solvent of said substance and said phospholipid (s), b) the solution of said substance and of said phospholipid (s) is mixed with an aqueous solution in an amount such that insolubilization in the form of a precipitate occurs, c) eliminating to recover an aqueous solution containing the microparticles in the form of microsuspensions. |