| abstract |
Condensed diazepinones of the general formula I in the one of the divalent residues X represents a = CH group or a nitrogen atom, R represents a lower alkyl radical which may optionally be substituted by a phenyl which may optionally carry halogen, methyl or methoxy, R 4 and R 5 represent hydrogen, halogen or lower alkyl, R 6 represents hydrogen Is chlorine or methyl, R 7 and R 8 are lower alkyl, R 8 is additionally halogen and m, n, o and p represent the numbers 0, 1, 2 or 3 with the following restrictions: the sum of m + n and the Sum of o + means the numbers 1, 2 or 3, the sum of n + o and the sum of m + p each the numbers 1, 2, 3, 4 or 5, however, the sum of m + n + o + p must always be greater than 2, and A 1 , A 2 , A 3 , A 4 are hydrogen or, in the event that m, n, o and p each represent the number 1, A 1 and A 2 together or A 3 and A 4 together represent an ethylene bridge, are suitable for the therapy of cholinergic spasms and motility disorders in the gastrointestinal tract, in the area of the laxative bile ducts, for the symptomatic therapy of cystitis and spasms in urelithiasis, for the therapy of relative incontinence, for the symptomatic therapy of bronchial and bronchial asthma and for the therapy of ischemic heart diseases. The compounds are distinguished by good selectivity. |