| abstract |
This invention relates to 4-methylene-2-oxo-8-azas-piro[4,5]decane derivatives of formula (I),n wherein nX represents oxygen or NR, wherein nR represents hydrogen or alkyl or cycloalkyl, or carbocyclic aryl or carbocyclic aryl-alkyl optionally substituted on the aromatic ring by one or more halogen atoms, alkyl or alkoxy . nPh¹ and Ph², which may be the same or different, each represent phenyl unsubstituted or substituted by one or more halogen atoms or alkyl, alkoxy, trihalomethyl or hydroxy optionally esterified by an alkanoic acid; and nn is 1 or 2; nand optical isomers and mixtures thereof, and all solvates, hydrates, acid addition and quaternary ammonium salts thereof, to pharmaceutical compositions containing these compounds and processes for their preparation. n The compounds of the formula (I) possess antipsychotic properties. Thus, they appear useful for the treatment of psychiatric disorders. |