| abstract |
The invention relates to 2-oxo-1-oxa-8-azaspiro[4,5]decane derivatives of formula (I),n n wherein nX represents oxygen or >NR, wherein R represents hydrogen or alkyl, cycloalkyl or tosyl , or carbocyclic aryl or carbocyclic aryl-alkyl optionally substituted on the aromatic ring by one or more halogen atoms, alkyl, alkoxy or trihalomethyl ; nR¹ and R² together represent methylene or, when X is a >NR , one of R¹ and R² may additionally represent hydroxyl whilst the other one is a methyl ; and nR³ represents hydrogen or benzyl, (alkoxy)carbonyl, phenoxycarbonyl, formyl, piperidin-1-ylcarbonyl, morpholin-4-ylcarbonyl, 4-methylpiperazin-1-ylcarbonyl, 4-(2-hydroxyethyl)piperazin-1-ylcarbonyl, 2-chloro-3-nicotinoylcarbamoyl or alkylcarbamoyl , and optical isomers and mixtures thereof and all acid addition and quaternary ammonium salts thereof, to pharmaceutical compositions containing these compounds and processes for their preparation. n The compounds of formula (1) possess anticonvulsive, antiallergic and lipid level lowering effects. Thus, they appear useful for the treatment of epileptic and allergic diseases and increased lipid levels. |