| abstract |
Compounds selected from the group consisting of imidazoles having the general formula (I) <CHEM> or their acid addition salts, and imidazolium salts having the general formula II <CHEM> wherein R is OR min or NR sec R''' R<1> is lower alkyl, benzyl; R<2> is hydrogen, lower alkyl, or cycloalkyl; R<3> is hydrogen, lower alkyl, or cycloalkyl; or R<2> and R<3> taken together form an alkylene chain of 3 to 10 carbon atoms; R<4> is lower alkyl, benzyl; X is an anion of a pharmaceutically acceptable salt; m is 0 or 1; and n is from 0 to 3; provided that when n is 0, m is 0. The compounds of general formulas I and II exhibit transglutaminase inhibiting activity and are useful in the treatment of thrombosis. |