| abstract |
Disclosed herein are peptide derivatives of the formula X[-NR¹-CH(R²)-C(W¹)] n -NH-CR³(R⁴)-C(W²)-NR⁵-CH[CH₂C(O)-Y]-C(W³)-NH-CR⁶-[CR⁷(R⁸)-COOH]-C(W⁴)-NH-CR⁹(R¹⁰)-Z wherein X is a terminal group, for example, alkanoyl or phenylalkanoyl radicals, R¹ is hydrogen, alkyl or phenylalkyl, R², R⁴ and R¹° are selected from amino acid or derived amino acid residues, R³, R⁵, R⁶, R⁷, R⁸ and R⁹ are hydrogen or alkyl, or R⁷ and R⁸ are joined to form a cycloalkyl, W¹, W², W³ and W⁴ are oxo or thioxo, Y is, for example, an alkyl or a cycloalkyl, Z is a terminal group, for example, COOH or CH₂OH, and n is 0 or 1. The derivatives are useful for treating herpes infections. |