| abstract |
The invention relates to a solid pharmaceutical dosage form from which the active ingredient or mixture of active ingredients is approximately pH-independent, i.e. independent of the hydrogen ion and hydroxyl ion concentrations and / or other ions and also independent of enzymes of the surrounding liquid, specifically after a certain time, i.e. after a certain time interval, quantitative or immediate release can go into solution, characterized in that the one active ingredient or a mixture of active ingredients, a water-swellable non-colloidal auxiliary (disintegrant) and at least one water-soluble carrier (osmosis-inducing substance) and optionally other dosage forms containing a semipermeable membrane is coated, which after a certain time opens like a lid and the active substance when aqueous liquid penetrates through the swelling pressure (detonation) of the swellable non-colloidal auxiliary and through the simultaneously occurring osmotic pressure and possibly internally generated gas pressure or releases the active ingredient mixture quantitatively. Furthermore, a method for producing and using the solid pharmaceutical dosage form. |