| abstract |
A compound of the formula (I);n wherein R 1 , R 2 , and R 3 are -COOR 4 , -COOR 5 , and -COOR 6 , respectively; R 4 , R 5 , and R 6 , are each hydrogen, lower alkyl, or alkali metal; W is hydroxyl; X, Y, and Z are each hydrogen or hydroxyl; the dotted line indicates the presence or absence of a single bond; and wherein W/R 3 , X/R 1 , and/or Z/R 3 may be combined together, to form a lactone, which compound is useful as a phospholipase A 2 inhibitor. A process for the production of the compound (I), a cell culture of a microorganism Circinotrichum falcatisporum RF-641 producing the same and pharmaceutical compositions containing the same are also provided. |