| abstract |
The invention relates to 3-carbalkoxyamino-5- (aminoacyl) -5H-dibenz [b, f] azepines of the formula I, in which mean: R¹ straight-chain or branched C₁₋₃ alkyl, R² is hydrogen, C₁₋₆ alkyl, which can be straight-chain, branched or ring-closed, aralkyl or β-oxethyl n 1, 2, 3, 4 or 5 and X -CH₂-CH₂- or -CH = CH-, and their salts, in particular the physiologically tolerable salts, wherein the compound of formula I with R¹ = ethyl, R² = methyl, n = 1 and X = -CH₂-CH₂- is excluded, a process for their preparation and pharmaceutical compositions with the compounds of formula I as active ingredients.n n n The process is based on the reaction of a 3-carbalkoxyamino-5-haloacyl-5H-dibenz [b, f] azepine with an amine to give the desired target product, which is optionally converted into a physiologically acceptable salt.n n n The compounds of the formula I can be used in the therapy of cardiac arrhythmias due to their pronounced antiarrhythmic effect. |