| abstract |
Compounds of structuren in which R 1 and R 2 are the same, or different and are each hydrogen, C 1 - 4 alkyl, -(CH 2 ) n Ar in which n is 0 to 4 and Ar is an optionally substituted phenyl group, or R 1 and R 2 together with the nitrogen atom to which they are attached form a saturated or unsaturated ring optionally containing one or more further heteroatoms, and R 3 and R4 are the same or different and are each hydrogen, C 1 - 4 alkyl, (CH 2 ) n Ar 1 in which n is 0 to 4 and Ar 1 is an optionally substituted phenyl group, or R 3 and R4 together with the nitrogen atom to which they are attached form a saturated or unsaturated ring optionally containing one or more further heteroatoms, R 5 is hydrogen, C 1 - 4 alkyl, C 1 - 4 alkoxy or COC 1 - 4 alkyl; n is 1 or 2; A is -SCH=CH-, -CH=C HS - or =C HSCH =, and the dotted line indicates the presence of a double bond when A is -SCH=CH- or -CH=CHS-; processes for their preparation, pharmaceutical compositions containing them and their use in therapy as anti-ulcer agents. |