| abstract |
The invention provides amide derivatives of the general formula (I)n wherein R¹ is a hydrogen atom or a C₁₋₆alkyl group; nY represents a group -(CH₂) m -, where m represents 2, 3 or 4 or a group -X(CH₂) p , where p represents 2 or 3, X represents an oxygen or a sulphur atom or a group NR⁵, where R⁵ is a C₁₋₆alkyl group, and X is attached to the benzene ring moiety of the molecule; and nIm represents an imidazolyl group of the formula:n wherein one of the groups represented by R², R³ and R⁴ is a hydrogen atom or a C₁₋₆alkyl, C₃₋₇cycloalkyl, C₃₋₆alkenyl, phenyl or phenylC₁₋₃alkyl group, and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C₁₋₆alkyl group; nand physiologically acceptable salts and solvates thereof. n The compounds of formula (I) are potent and selective antagonists of 5-hydroxytryptamine at 5-HT₃ receptors and are useful, for example, in the treatment of psychotic disorders, anxiety and nausea and vomiting. |