| abstract |
Compounds represented by the following structural formula (I):n wherein q is O or 2; nR₁ is (L) a -(CH₂) b -(T) c -M na is 0 or 1; nb is 3 to 14; nc is 0 or 1; nL and T are independently oxygen or CH₂; nM is C₁₋₄ alkyl, ethynyl, trifluoromethyl, isopropenyl, furanyl, thienyl, cyclohexyl or phenyl optionally monosubstituted with Br, Cl, CF₃, alkoxy, alkyl, methylthio, or trifluoromethylthio; nY is (CHX)(CH₂) p -Z wherein nZ is COR₃, or tetrazolyl; in which nR₃ is OH, NH₂, aryloxy, or C₁₋₆ alkoxy; np is 0, 1 or 2; nX is OH, or alkoxy; nR is -(CH₂) p -W; nd is 0 to 6; nW is phenyl substituted with B, C, or D; nB is-(CH₂) p -V wherein p is 0 to 6 and V is COR₃, SO₃H, SO₂H, SO₂NH₂, COCH₂OH, CHOHCH₂OH, or tetrazolyl, with R₃ as defined above; nC and D are independently selected from H, OH, F, Cl, Br, CF₃, alkyl, alkoxy, methylthio, trifluoromethylthio, NO₂, NH₂, NHalkyl, or CalkylCO-; or npharmaceutically acceptable salts thereof, can be used in the preparation of a medicament for the treatment of asthma. |