| abstract |
The invention concerns known and novel compounds which fall under the general formula:n wherein A encompasses a wide range of values including but not limited to aryl, loweralkyl, cycloalkyl, and carbohydrates including sucrose and fructose; p is equal to the number of hydroxy groups on A and may be zero; z is the number of -OS(O) 2 NR 1 R 2 groups and is always at least one; R 1 and R 2 are selected from hydrogen, loweralkyl, carboxy and the like; which compounds are useful for treating chronic arthritis and osteoporosis. A novel process for preparing the compounds is provided wherein an appropriate sulfamic acid aryl ester is reacted with a a hydroxy substituted A radical which may or may not contain thereon protected carboxyl, amino or hydroxy substituents, in an aprotic solvent containing a tertiary amine base. Pharmaceutical compositions for the treatment of chronic arthritis and osteoporosis are also provided. |