| abstract |
This invention relates to compounds of the formula:n n wherein R is an electron withdrawing group; nR₁ is H or COZ; nX₁ and X₂ are independently H, lower alkyl, aryl, aryl lower-alkyl or polystyrene or nR and X₁ taken together with the carbon atoms to which they are attached form a ring containing from 4 to 15 ring carbon atoms and may contain up to 2 heteroatoms, wherein the heteroatoms are O, S, or N; and nZ is an amino acid residue, a peptide residue or a leaving group. The compounds of the present invention are adaptable as blocking or protecting groups for an amine composition useful in peptide synthesis. The present invention is also directed to a method of protecting an amino group of an organic molecule during a reaction which modifies a portion of the molecule other than the protected amino group. |