| abstract |
The invention concerns novel renin-inhibitory compounds of formula I <CHEM> which contain an amino-substituted heterocycle at the P2 position. These are useful for treating renin-associated hypertension, congestive heart failure, glaucoma, hyperaldosteronism, and diseases caused by retroviruses including HTLV-I and -III. Processes for preparing the compounds, compositions containing them, and methods of using them are included. Also included is a diagnostic for determining the presence of renin-associated hypertension, or hyperaldosteronism. |