http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0398997-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb9c6b40161bafe7bd55f0b4defcea04 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-19 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate | 1989-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2ca84c5d73b09db104f039615aaf889 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5162ac20faed43f7ca004e8406a69668 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85b24e4f2e6efbd54e75e7c025fcfde6 |
| publicationDate | 1990-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0398997-A1 |
| titleOfInvention | GENES AND THEIR ENCODED PROTEINS REGULATING THE GENE EXPRESSION OF THE INTERLEUKIN-2 RECEPTOR AND HUMAN LYMPHOTROPIC RETROVIRUSES. |
| abstract | This invention relates to genes called Rpt-1 (regulatory protein T lymphocyte-1) expressed at higher levels by resting CD4 + T helper / inducer cells compared to activated CD4 + cells. The invention also relates to proteins encoded by such genes, called rpt-1 proteins, which regulate gene expression caused by the activator region of the alpha-chain gene of the interleukin-2 receptor (IL-2r) or by activator region of the repeated terminal sequence of human lymphotropic retroviruses such as human immunodeficiency virus type 1 (HIV-1), human T cell leukemia virus (HTLV) -I, and in particular HTLV-II. The rpt-1 proteins negatively regulate gene expression driven by the activator of the HIV-1 repeat terminal sequence. The proteins and nucleic acids of the invention are useful in the diagnosis and therapy of immune disorders such as AIDS. An Rpt-1 gene and its encoded intracellular protein of molecular weight of approximately 41,000 daltons are described in a specific example of the present invention. The rpt-1 protein is presented as being selectively expressed by activated CD4 + T cells, and negatively regulating the gene expression of IL-2r and HIV-1. |
| priorityDate | 1988-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 556.