| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_be944a7839fc8cabe752928d03dafaa4 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-815
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-81 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-865 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-815
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-99
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-81
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 |
| filingDate |
1990-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1994-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4d066af49a3f266aa88fecd0fc01020
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a68c2ad3f5d932fcb2ca2d5e504d26be
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05ca39dd82fca5973bc519268ed7ae31 |
| publicationDate |
1994-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0396436-B1 |
| titleOfInvention |
Improved yeast strains for the production of mature heterologous proteins, in particular of hirudin |
| abstract |
The invention relates to an improved system for the production of mature heterologous proteins, and in particular of hirudin, by yeasts, comprising an expression vector containing a sequence coding for the heterologous protein. This improvement is characterised by the amplification of the yeast KEX2 gene coding for the yscF endoprotease. The amplification is carried out either by integration of one or more copies of all or part of the KEX2 gene in the genome of the yeast, or by insertion of one or more copies of all or part of the KEX2 gene in the vector for expression of the heterologous protein. <IMAGE> |
| priorityDate |
1989-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |