| abstract |
N-[(alkylamino)alkyl]-4,5-diaryl-1H-imidazole-1-acetamides of formulan or acid-addition salt thereof wherein R¹ and R² are independently hydrogen, hydroxy, lower-alkyl, lower-alkoxy, nitro, or halo; R³ and R⁴ are independently hydrogen, lower-alkyl, or hydroxy lower-alkyl, or R³ and R⁴ together form a straight or branched alkylene chain of four to six carbons; A is CH₂CH(OH)CH₂ or (CH₂) n wherein n is an integer from two to eight, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of a diaryl imidazole-1-acetic acid with an appropriate diamine. |