http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0391005-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-46 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-26 |
| filingDate | 1989-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1991-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1991-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0391005-B1 |
| titleOfInvention | Process for the production of alpha-6-deoxytetracyclines |
| abstract | A process for the hydrogenation of a 6-methylene-tetracycline in the production of alpha-6-deoxytetracycline, particularly the antibiotic doxycycline, in the presence of a transition metal complex of the formula MClx(PPh3)y wherein M is preferably Cu, Co or Ni, x is 1 or 2 and y is 1-3, and a trace of rhodium either as the supported metal or as a rhodium salt, as a hydrogenation catalyst. The desired alpha-6-deoxytetracycline product is produced in high yields and stereospecificities. The process requires the use of substantially cheaper transition metal complexes and only traces of rhodium in the hydrogenation catalyst per mole of the 6-methylene tetracycline hydrogenated. |
| priorityDate | 1989-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.