| abstract |
Hypoglycemic thiazolidine-2,4-dione derivatives of the formulan wherein the dotted line represents a bond or no bond; nV is -CH=CH-, -N=CH-, -CH=N-, S, O or NR; nW is S, SO, SO₂, SO₂NR¹, NR¹SO₂, CONR¹ or NR¹CO; nX is S, O, NR², -CH=N- or -N=CH; nY is CH or N; nZ is hydrogen, (C₁-C₇)alkyl, (C₃-C₇)cycloalkyl, phenyl, pyridyl, furyl, thienyl or phenyl mono- or disubstituted with the same or different groups which are (C₁-C₃)alkyl, trifluoromethyl, (C₁-C₃)alkoxy, fluoro, chloro or bromo; nZ¹ is hydrogen or (C₁-C₃)alkyl; nR, R¹ and R² are each independently hydrogen or (C₁-C₄); and nn is 1, 2 or 3; na pharmaceutically acceptable cationic salt thereof; or na pharmaceutically acceptable acid addition salt thereof when the compound contains a basic nitrogen. |