| abstract |
Anthracycline glycosides of general formula I:n wherein Z is hydrogen or methoxy; nX represents hydrogen or hydroxy; nR₁ represents hydrogen, fluorine, hydroxy, methoxy or amino; nR₂ and R₃ both represent hydroxy or one of R₂ and R₃ is hydrogen, nitro or amino and the other is hydroxy; and nR₄ and R₅ represent hydrogen or one of R₄ and R₅ is hydrogen and the other is hydroxy; nand pharmaceutically acceptable salts thereof; with the provisos that: n(i) when R₂ and R₃ are both hydroxy and Z is hydrogen then R₁ represents hydroxy, fluorine or amino, and (ii) when both Z and R₁ are methoxy and R₂ and R₃ are both hydroxy then R₅ is hydroxy or both R₄ and R₅ are hydrogen. |