| abstract |
A derivative of 5-hetero-6-oxo-PGE of the formula:n wherein R¹ isn (1) a group of the formula: COOR11 wherein R11 is hydrogen or an esterifying group; (2) hydroxymethylcarbonyl, (3) hydroxymethyl or (4) a group of the formula: CO-AA nwherein AA is an amino acid -residue, Z is oxygen, sulfur or an amino group, nR2 is a single-bond or alkylene, nR3 is alkyl, cycloalkyl, phenyl or phenoxy, and ----- is single-bond or a double bond, non-toxic salts thereof or cyclodextrin clathrate thereof possess PG-like activity, especially cytoprotective activity. |