| abstract |
The invention relates to new acyl derivatives of rifamycins of the formula and their salts, in which the structural elements -A 1 -A 2 -, -A 3 -A 4 - and -A s -A s - each ethylene or vinylene or the elements -A 1 -A 2 - and -A 3 -A 4 - each represent ethylene and -A 5 -A 6 -vinylene; X for C (R 6 ) - or Is N- and R 6 is hydrogen or alkyl; alk represents an aliphatic hydrocarbon residue; R represents hydrogen or acyl; R 2 is acyl and R 3 and R3 are bonded together or R 3 is hydrogen or acyl and R 3 'is hydrogen; R 4 represents hydrogen, cycloalkyl or aryl; R s represents hydrogen or acetyl; R 7 represents hydrogen or alkyl, which can be used as active pharmaceutical ingredients, their manufacture and use, and pharmaceutical preparations and their manufacture. |