http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0385354-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3b9f373878f16dc291ff597162e9b344 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C50-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C46-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C46-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J27-128 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-727 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C50-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C50-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-423 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 |
| filingDate | 1990-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc0177da66f4e68838b95b6874cb271f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36b0bf542d0522106403420a488171b2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d87d46fae01ec521bc0d6e6be097b38e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3536da5266e2207fbe89a7c4da4662bc |
| publicationDate | 1990-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0385354-A1 |
| titleOfInvention | Process for preparing anthracyclinones |
| abstract | Process for preparing anthracyclinones of general formula (I):n wherein R represents a hydrogen atom or a COOR₁ group in which R₁ may be a hydrogen atom or an optionally substituted C₁-C₁₀ alkyl group, which are intermediates in the preparation of antitumor anthracycline glycosides, are prepared by:n (i)(a) reacting a 4-demethyl-4-sulfonyl-7-deoxy-13-dioxolanyl daunomycinone of formula (V):n wherein R′ represents an alkyl group having from 1 to 10 carbon atoms optionally substituted by one or more halogen atoms or an aryl group optionally substituted by halogen, alkyl, alkoxy or nitro, in a reducing environment with a catalytic amount of a compound of formula (VIII): nML n L′ m nwherein M represents a transition metal atom, L and L′, which may be the same or different, each represent an anion or a neutral molecule and n and m may vary from 0 to 4, such as to obtain a compound of formula (VII): n wherein R represents hydrogen; or n(b) carbonylating a 4-demethyl-4-sulfonyl-7-deoxy-13-dioxolanyl daunomycinone of formula (V) as defined above, with carbon monoxide in the presence of a nucleophile R₁OH wherein R₁ is as defined above, an organic or inorganic base and as catalyst a compound of formula (VIII) as defined above, such as to obtain a compound of formula (VII) as shown above wherein R represents a COOR₁ group; and (ii) introducing an α-hydroxy group at the 7-position and removing the 13-oxo protecting group by acid hydrolysis from the resultant compound of formula (VII). |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006024016-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006024016-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0125179-A1 |
| priorityDate | 1989-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 90.