| abstract |
Compounds of formula (I):n [in which: R 1 is heterocyclic group having 5 or 6 ring atoms, or -NR 7 R 8 , where R 7 is alkyl and R 8 is optionally substituted phenyl, optionally substituted phenylalkyl or cycloalkyl; R 2 is optionally substituted phenyl or naphthyl; R 3 is thiazolyl; R 4 is cyclohexyl or isopropyl; R 5 is alkyl; and R 6 is alkyl] and salts thereof have renin-inhibitory and, hence, hypotensive activities and are of value in the diagnosis and treatment of hypertension induced by failures in the renin-angiotensin system. They may be prepared by reacting together appropriate amino acids or derivatives thereof. |