| abstract |
Process for the manufacture of a pharmaceutical composition composed of an organic acid derivative of alpha tocopherol, and which can also comprise other lipids. The composition can be in the form of liposomes associated, as such, with a bioactive agent or trapping the latter. Medicines stable at an acidic pH level are particularly suitable for such systems, for example drugs containing imidazole groups, such as pilocarpine. The composition requires a stabilizer in order to maintain a double layer phase of the organic acid derivative of alpha tocopherol, in a low pH environment. Such a stabilizer can for example be a detergent. During in vivo administration of the system and a concomitant increase in pH, the viscosity of the preparation increases. |