| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dd89d77edade2f51432063328b1932e6 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 |
| filingDate |
1989-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f98a30794e36fdf8119518461409311b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_764aa0f841a81ae9f6352d9d4d3e70ee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9a718c7522fe76ac429d68bc97e1a0b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1676bce351f474a46964a01bb8be122f |
| publicationDate |
1990-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0381750-A1 |
| titleOfInvention |
METHOD FOR TREATING AND PREVENTING LOSS OF BONE MASS. |
| abstract |
The invention describes and claims the use of alpha-vitamin D2 as a medicament in the treatment of osteoporosis. Active vitamin D3 compounds are ineffective or have minimal efficacy at dosage levels that can be tolerated by humans. At dosage levels required in order to effectively replenish lost bone mass, active vitamin D3 compounds exhibit an amount of serious toxicity in the form of hypercalcemia and hypercalciuria. The inventors have discovered that 1alpha-vitamin D2, which is as active as 1alpha-vitamin D3 for stimulating the intestinal absorption of calcium, can be administered safely at dosages greater than 3.0 mug / day without stimulating reabsorption. bone. |
| priorityDate |
1988-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |