http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0381713-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07addebfc9446dc5a9a77692ebf4dac1 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2121-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2123-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C319-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F13-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D285-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-081 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0478 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C319-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-06 |
| filingDate | 1989-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1994-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e30c509cfe24e40ccbb6549edf288bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_421f40d384b3049dd316f7509de6780d |
| publicationDate | 1994-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0381713-B1 |
| titleOfInvention | Diaminedithiol chelating agents for radiopharmaceuticals |
| abstract | The invention relates to a method of preparing a diaminedithiol chelating agent by reacting a cyclic diamine disulfide with a thiol compound as a reducing agent, said thiol compound being selected from the group consisting of dithiothreitol, dithioerythritol, thioglycol, cysteine, N-acetylcysteine, glutathione, alpha-mercaptopropionylglycine, 4-mercaptopyridine, 2, 3-dimercapto-1-propanol, 1,4-dimercaptobutane and 1,3-dimercaptopropane. The invention further relates to a new N2S2-compound having general formula (III), wherein Z, Z1, Z2 and Z3 are equal or different and represent methylene groups, if desired substituted with one or two C1-C4 alkyl group(s), or carbonyl groups; R2, R3, R4 and R5 are equal or different and represent C1-C4 alkyl groups; R7 is a hydrogen atom or a C1-C16 hydrocarbyl group, if desired substituted with a pharmaceutically acceptable target specific group, derived from a compound selected from the group consisting of a protein or proteinaceous substance, a receptor binding agent and an amino compound, or with a group permitting derivatization to a target specific group, said group permitting derivatization being selected from the group consisting of a halogen atom, an aldehyde group, a carboxy group and an activated ester group; R8 is a hydrogen atom or a C1-C16 hydrocarbyl group, if desired substituted with said pharmaceutically acceptable target specific group or with said group permitting derivatization to a target specific group; R9 is a hydrogen atom or a C1-C4 alkyl group; and Y is a hydrogen atom or a suitable protective group; or a salt of this compound with a mineral or organic acid. |
| priorityDate | 1988-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 354.