| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fdaa64756184e715af6cb25ebc318917 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-975
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-745
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-81 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-78 |
| filingDate |
1989-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4897692c7885af007e46a6187418ee2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_986a76dfbe4159641a3cb01e36c1911d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_680c0104f2e120233714e708d05d94ba |
| publicationDate |
1990-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0376189-A2 |
| titleOfInvention |
Kit or reagent for assaying the cellular integrity of blood platelets and pharmaceutical compositions containing a PKA inhibitor |
| abstract |
There is provided a kit or reagent for assaying the cellular integrity (intactness) of blood platelets comprising means for determining the quantity of PKA released by a number of platelets into a certain volume of plasma. The assay is based on determining cAMP-dependent phosphorylation of vitronectin (protein S) in plasma using radioactively labelled) [γ³²P]ATP as phosphate donor. The assay can be based on the specific inhibition of the phosphorylation in blood fluid by protein kinase inhibitors. The invention further relates to pharmaceutical compositions for the treatment of pathological conditions associated with impaired platelet function in humans, which comprises administering to a person in need thereof a physiologically active quantity of a PKA inhibitor adapted to decrease or prevent vitronectin phosphorylation. The inhibitor can be a synthetic or genetically engineered peptide. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5922844-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5629287-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018137396-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2037277-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2002543851-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6949351-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9748802-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009034120-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0070082-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5610148-A |
| priorityDate |
1988-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |