| abstract |
7-Oxabicycloheptane substituted prostaglandin analogs which are thromboxane A 2 (TxA 2 ) receptor antagonists or combined thromboxane A 2 receptor antagonists/thromboxane synthase inhibitors useful, for example, in treating thrombotic and vasospastic disease have the structural formulan wherein m is 1, 2 or 3; n is 0, 1, 2, 3 or 4; Z is -(CH 2 ) 2 - or -CH=CH-, with the proviso when Z is -CH = CH-, n is 1, 2, 3 or 4; R is C0 2 H, CO 2 lower alkyl, CH 2 OH, CO 2 alkali metal, CONHSOR 3 , CONHR 3a or -CH 2 -5-tetrazolyl, X is 0, S or NH; and where R 1 , R 2 , R 3 and R 3a are as defined herein. |