| abstract |
The present invention provides propanamines, substituted at the 3-position of the propanamine chain with a thio, sulfinyl or sulfonyl moiety, of the formula <CHEM> wherein: R is phenyl, substituted phenyl, naphthyl, substituted naphthyl, thienyl, halothienyl, (C1-C4 alkyl)-substituted-thienyl, furanyl, halofuranyl, (C1-C4 alkyl)-substituted-furanyl, pyrrolyl, halopyrrolyl or (C1-C4 alkyl)-substituted-pyrrolyl; R<1> is phenyl, substituted phenyl, C5-C7 cycloalkyl, thienyl, halothienyl, (C1-C4 alkyl)-substituted-thienyl, furanyl, pyridyl or thiazolyl; R<2> and R<3> are each independently hydrogen or methyl; n is 0, 1 or 2; and the pharmaceutically acceptable acid addition salts thereof. They are capable of selectively inhibiting the uptake of serotonin and norepinephrine. |